understand then help

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Treating genetic lysosomal diseases due to defective membrane transporters poses a formidable challenge. This team studies cystinosis, a disease due to storage of a special amino-acid, cystine, when its lysosomal membrane exporter does not work : cystine accumulates and crystallizes, causing cell suffering then death everywhere in the body, starting by the kidneys.
Deciphering a mechanism of cystinosis progression led to the identification of a novel way to alleviate cystine accumulation : by interfering with lysosomal cystine supply using other natural amino-acids as competitors. We are currently testing this strategy in laboratory rodents mimicking the human disease. This work is generously supported by a US-based charity, the Cystinosis Research Foundation.

For more information: https://www.deduveinstitute.be/epithelial-differentiation

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— understand then help

The de Duve Institute is a multidisciplinary biomedical research institute hosting several research laboratories of the Faculty of Medicine of the UCLouvain, as well as the Brussels branch of the Ludwig Institute for Cancer Research.

The de Duve Institute is based on three key principles:
- priority to fundamental research and freedom of researchers,
- special attention to the medical benefits that may result from fundamental discoveries,
- multidisciplinary collaboration in an environment of skills, techniques and equipment.

The money raised during the crowdfunding campaign will allow the Institute to purchase state-of-the-art equipment and foresee grants to recruit exceptional scientists. By donating you are accelerating research.

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